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KMID : 1161420230260060379
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Journal of Medicinal Food
2023 Volume.26 No. 6 p.379 ~ p.389
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Efficacy of Veronica incana for Treating Osteoarthritis Induced by Monosodium Iodoacetate in Rats
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Jin A. Lee
Trung Huy Ngo
Shin Mi-Rae
Choi Jeong-Won
Choi Hyuk-Jae
Nam Joo-Won
Roh Seong-Soo
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Abstract
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The aim of this study is to investigate the efficacy and the underlying mechanism of Veronica incana in osteoarthritis (OA) induced by intraarticular injection of monosodium iodoacetate (MIA). The selected major four compounds (A?D) of V. incana were found from fractions 3 and 4. Its structure elucidation was determined by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) data analysis and nuclear magnetic resonance (NMR) data comparison with literature. MIA (50?μL with 80?mg/mL) for the animal experiment was injected into the right knee joint. The V. incana was administered orally every day to rats for 14 days from 7 days after MIA treatment. Finally, we confirmed the four compounds: (A) verproside; (B) catalposide; (C) 6-vanilloylcatapol; and (D) 6-isovanilloylcatapol. When we evaluated the effect of V. incana on the MIA injection-induced knee OA model, there were a noticeable initial decreased in hind paw weight-bearing distribution compared to the Normal group (P?
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KEYWORD
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anti-inflammatory, MIA, osteoarthritis, Veronica incana
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